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Stem Cell Surface Markers and Their Role in Cancer Progression

Samane Heidarzade, Seyed Mohammad Amin Kormi , Nasrin Malekpour, Shima Ardehkhani

Samane Heidarzade
Department of Biology, Faculty of Science, University of Zabol, Zabol, Islamic Republic of Iran

Seyed Mohammad Amin Kormi
1. Department of Biology, Faculty of Science, University of Zabol, Zabol, Islamic Republic of Iran 2. Cancer Genetics Research Unit, Reza Radiation Oncology Center, Mashhad, Iran. Email: aminkormi@gmail.com

Nasrin Malekpour
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Shima Ardehkhani
University of Applied Science and Technology, Tehran, Iran
Online First: February 27, 2017 | Cite this Article
Heidarzade, S., Kormi, S., Malekpour, N., Ardehkhani, S. 2017. Stem Cell Surface Markers and Their Role in Cancer Progression. Journal of Genes and Cells 3(1): 1-5. DOI:10.15562/gnc.48


Cancer progression and metastasis is rarely or less studied phenomenon. It has been known that cancer stem cells are the significant agents playing critical in metastasis and advanced tumorigenesis because of their heterogeneous nature. Their changed molecular expression with the passage of time and induction of normal cells into cancerous cells are correlated and determining these stem cell markers expression on CSCs can help to understand the progression of cancer and resistance to chemotherapy approaches. Identification of these signaling pathways and their modulation role are the key necessities for precise diagnosis and targeted therapeutic approaches development.

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