Review Article

Genetics and Epigenetics of Celiac disease: Heads or Tails?

Pedram Torabian, Mohamad Dehestani, Azra Izanloo, Narges Jafarzadeh, Azita Ganji, Kamran Ghaffarzadegan

Pedram Torabian
Imam Reza International University

Mohamad Dehestani
Mashhad University of Medical Sciences

Azra Izanloo
Imam Reza International University

Narges Jafarzadeh
Imam Reza International University

Azita Ganji
Mashhad University of Medical Sciences

Kamran Ghaffarzadegan
Imam Reza International University. Email: kghafar46@gmail.com
Online First: December 31, 2018 | Cite this Article
Torabian, P., Dehestani, M., Izanloo, A., Jafarzadeh, N., Ganji, A., Ghaffarzadegan, K. 2018. Genetics and Epigenetics of Celiac disease: Heads or Tails?. Journal of Genes and Cells 4(2): 67-75. DOI:10.15562/gnc.65


Celiac is a serious gluten sensitive enteropathy which is caused by autoimmune reaction based on genetics and epigenetics factors. About 3 million Americans suffer from this disorder. The symptoms occur when gluten is consumed and thereafter, autoimmune responses manifest. This disorder is first described in a child but it may happen at any age especially after impacts of triggers. Many genetics and epigenetics are involved in this disease including HLA genes DQ and other like CTLA4, IL2, IL21, MYO9B, etc. Considering the epigenetics factors, histon modifications and also miRNAs activities inside the body is verified and the affection is investigated. To unravel new treatments for celiac disease, new approaches for instance next generation sequencing in affected people is desired and look for modern and also alternative treatments are needed.

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