Review Article

Hair Follicle Stem Cell: Molecular Basis of Development, and Regeneration

Shirin Farivar , Mahboobeh RojhanNejad

Shirin Farivar
Shahid Beheshti University (GC). Email:

Mahboobeh RojhanNejad
Shahid Beheshti University (GC)
Online First: July 01, 2015 | Cite this Article
Farivar, S., RojhanNejad, M. 2015. Hair Follicle Stem Cell: Molecular Basis of Development, and Regeneration. Journal of Genes and Cells 1(3-4): 57-66. DOI:10.15562/gnc.20

One of the accepted models for tissue homeostasis is the capability of stem cells for self renewal with the aid of asymmetric cell division which can give rise to a new stem cell and a daughter progenitor cell. Hair follicle can reconstitute itself in a regulated cyclical program, which suggests the presence of stem cells in it. Hair follicle morphogenesis takes place in epidermis developmental stage and strongly depends on ectoderm-mesoderm interactions and regulated signaling pathways such as Wnt, Notch, Sonic Hedgehog and Bmp. Also recent investigations have proved heterogeneity of follicle stem cells and their dynamic nature in growth cycles. Studies show that bulge cells have high proliferation potential and multipotency, and are capable to regenerate hair follicle, epidermis, and sebaceous gland as well. Moreover, identification of cell surface markers helped researchers to isolate enriched bulge cell populations from human and mouse follicles. Future treatments for follicle disorders and potential gene therapy applications in other related diseases such as tumors originating from follicle stem cells would be possible using these specific markers.

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