Adoptive Cell Transfer to Enhance Patients Immunity Against Cancer

Muhammad Irfan-Maqsood , Monireh Bahrami, Raheleh Amirkhah

Muhammad Irfan-Maqsood
Jinnah Stem Cell Institute (JSCI), Islamabad. Email:

Monireh Bahrami
Ferdowsi University of Mashhad

Raheleh Amirkhah
University of Tehran
Online First: July 01, 2015 | Cite this Article
Irfan-Maqsood, M., Bahrami, M., Amirkhah, R. 2015. Adoptive Cell Transfer to Enhance Patients Immunity Against Cancer. Journal of Genes and Cells 1(3-4): 67-70. DOI:10.15562/gnc.21

Cancer is an abnormality of cells in which cells are proliferating in an uncontrolled manner due to some unwanted mutations. Any cells from any part of body can be cancerous and may form tumors later on. These tumors develop tumorsphere and their microenvironment modulate T cells as a survival mechanism and these immune cells failed to identify the cancerous cells, allowing them to metastasis. A number of therapeutic approaches such as radiotherapy, chemotherapy etc. are being applied in clinical practices to remove tumors or kill tumor cells. Cell therapy has shown a promising potential in last two decades in cancer treatment as some cells such as mesenchymal stem cells have tumor tropism and induce apoptosis in cancer cells. Recently, immunotherapeutic approaches have been considered the gold standard and it has been shown that T cells isolated from the cancer patient can be trained to target cancer cells. In this process, chimeric antibody receptor (CAR) and T-cell receptor (TCR) are introduced on the T cell surface to enhance T cells function and their transfer in the patient’s circulatory system result in the identification and killing of cancerous cells. This approach has been known as the adoptive cell transfer or adoptive cell therapy (T cells) and has shown 99% promising results in 243 clinical trials done so far. Clinical trials are going on to determine its efficacy in cancer treatment and a number of pharmaceutical firms are developing adoptive T cells as drugs to treat cancer in our daily routine clinical practice. Results obtained yet, have shown the perspective of adoptive cell therapy as the future approved cancer therapy.

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