<PublisherName>Pakistan Society for Gene and Cell Therapy</PublisherName>
<JournalTitle>Journal of Genes and Cells</JournalTitle>
<ArticleTitle>Generation of Cancer Fighting Cells (CFCs): A Cell Engineering Approach</ArticleTitle>
<Affiliation>Stem Cell and Regenerative Medicine Research Group, Iranian Academic Center for Education, Culture and Research (ACECR), Khorasan Razvi Branch, Mashhad, Iran. hojjat_naderi@yahoo.com</Affiliation>
<Abstract>Engineering cells is a novel approach to enhance efficacy of cell therapy in which therapeutic cells like mesenchymal stem cells (MSCs), T-Cells etc are engineered to enhance their specific therapeutic features. These cells because of their specific therapeutic features, can also be termed as cancer fighting cells (CFCs)  For example, tumour-directed migration capabilities of MSCs have been enhanced by engineering MSCs for targeted cancer therapy. MSCs have also been engineered to express anti-proliferative, pro-apoptotic, anti-angiogenic agents. A number of T cells have also been engineered to express TCRs (T-cell receptors) or CAR (chimeric antigen receptors) and have shown promising results in clinical trials. A number of diseases such as leukaemia have been treated using engineered cells, successfully. Further clinical trials are required to justify the hypothesis and to improve engineering approaches for regular clinical practices.</Abstract>
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